Research Assistant, Research and Development

Talaris Therapeutics, Inc. (“Talaris”) is a late-clinical stage biotechnology company that is developing transformative cell therapies with the potential to eliminate the burden of chronic immunosuppression for organ transplant recipients as well as induce durable remissions in patients with severe autoimmune and immune-mediated disorders.  Achieving durable, drug-free immune tolerance to a donated organ has been referred to as a “Holy Grail” of organ transplant. In a ground-breaking, phase 2 study conducted between 2009 – 2016, our lead therapy, FCR001, enabled 70% of living donor kidney transplant recipients to be weaned off all immunosuppression within 12 months of their kidney transplant, without rejecting their donated organ.  The benefits of our therapy have been shown to be extremely durable.  We have followed these patients for an average of over five years since their transplant, and the longest for over ten years, and not a single patient who was tolerized in our phase 2 study has subsequently had to resume immunosuppression.  Since late-2018, Talaris has raised over $190M in private financing from leading life sciences investors and has initiated a Phase 3 registration trial of our therapy in living donor kidney transplant patients. In 2021, the company also plans to initiate Phase 2 trials of FCR001 in scleroderma as well as in patients who have previously received a living donor kidney transplant. Our cell processing facility is based in Louisville, KY, and we have a corporate office in Boston, MA

Job Title:                   Research Assistant, R&D
Schedule:                  Full-time (1st/2nd Shift)
Location:                   Louisville, KY
Reports to:                Head of Research
Direct Reports:         N/A

Position Summary:

A Research Assistant, to be based in Louisville, KY is responsible for supporting analytical sample testing related to the research and development of novel cell therapy products under the supervision of a Senior Scientist for preclinical and clinical research and development as well as day-to-day operations related programmatic organization activities. The primary responsibilities of this role are sample processing and performing analytical test methods for preclinical and clinical R&D samples with a focus on flow cytometric analysis; secondary responsibilities include cross-training in Good Manufacturing Practices (GMP) to support GMP Quality Laboratory operations and analytical testing for production of cell therapy products.

Principal Duties and Responsibilities:

  • Participate in preclinical and clinical research and development sample processing, PBMC isolation and sample analysis
  • Train on flow cytometric analysis and cell-based assays as necessary
  • Conduct data analysis and tabulation of results
  • Support general laboratory duties including routine equipment maintenance, inventory management and ordering, facility monitoring and maintenance
  • Adherence to established analytical test methods and SOPs as well as support preparation and revisions of SOPs
  • Ability to work in fast-paced collaborative environment with cross-functional teams
  • Perform related duties as assigned in an efficient and organized manner to meet schedules and deadlines
  • Demonstrate understanding and/or application of fundamental scientific principles, industry standards and regulatory guidance
  • Maintain accurate and reliable records and all other pertinent documentation

Secondary Responsibilities:

  • Train on approved SOPs and participate in QC analytical test methods for cell therapy products including but not limited to endotoxin, sterility, cell counting, and cell-based assays related to product potency
  • Adherence to appliable regulations and standards including GMP, Good Tissue Practice (GTP) and American Association of Blood Bank (AABB) standards
  • Support general maintenance of QC equipment as well as the qualification and validation of analytical test methods
  • Responsible for maintaining up to date training requirements
  • Perform related duties as assigned

 Minimum Education, Training, and Experience Required:

  • Associate or Bachelor’s degree in Biology, Immunology of related field of Science with a minimum of 1 year equivalent laboratory experience in an academic and/or industry setting
  • Experience in flow cytometry, molecular biology, clinical diagnostics, cell isolation and culturing, sample processing, or blood banking preferred
  • General understanding of hematology and immunology concepts
  • Good Manufacturing Practices (GMP), Good Tissue Practice (GTP), and American Association of Blood Banks (AABB) standards preferred
  • Please note: an equivalent combination of education, training, and/ or professional experience may be considered in substitute for requirements listed

 Additional Qualifications

  • General experience working in a laboratory environment and following standard operating procedures for complex, advanced analytical methods preferred
  • Knowledge of technical skills, analytical skills, and solutions-oriented approach to problem-solving
  • General lab skills and knowledge of lab safety, including universal precautions, and sterile technique
  • Flexibility and dedication: Position will require “off-standard hours” including weekends and “on-call” hours as related to specific clinical trials

 Physical Requirements:

  • Prolonged period of standing, sitting and working on a computer.
  • Must be able to lift 50 pounds at times.
  • Ability to work some irregular hours, including evenings or weekends, depending on workload

 Benefits:

  • Health insurance
  • Dental insurance
  • Vision insurance
  • Paid time off 25 days
  • Stock Options
  • 401k
  • Employer paid short and long term disabillity

Apply: Please submit resume or CV and cover letter to hiring@Talaristx.com

Talaris is fully committed to equality of opportunity in all aspects of employment. It is the policy of Talaris to provide equal employment opportunity to all employees and applicants without regard to race, color, religion, national or ethnic origin, military status, veteran status, age, gender, gender identity or expression, sexual orientation, genetic information, physical or mental disability or any other protected status.