Our Approach

Immune tolerance

The immune system plays a vital role in our health, and is composed of cells that mature from hematopoietic stem cells (HSCs).

HSCs are immature cells found primarily in the bone marrow that can develop into all types of blood and immune cells. A fundamental quality of a healthy immune system is its ability to distinguish “self” from “non-self” (e.g., transplanted organs, infectious agents or cancerous cells). “Non-self” substances generate an immune attack. The immune system’s natural process for not mounting an immune attack to “self” is referred to as immune tolerance. However, in some cases immune-mediated attack of substances deemed “non-self” is detrimental. Three primary examples of this are:

1. Solid Organ Transplantation

2. Severe Autoimmune Disease

3. Severe Non-Malignant Blood, Immune, and Metabolic Disorders

Our Approach: Facilitated Allo-HSCT Therapy

Our proprietary therapeutic approach, Facilitated Allo-HSCT Therapy, is designed to induce immune tolerance. It does so by creating chimerism.  

Chimerism refers to a state in which both the donor’s HSCs and the recipient’s HSCs co-exist in the recipient’s bone marrow. These co-existing HSCs in turn produce blood and immune cells of both donor and recipient origin. These cells mutually recognize the other as “self,” thereby evading immune-mediated rejection and graft versus host disease (GvHD).

Chimerism is the state in which both the donor’s HSCs and the recipient’s HSCs co-exist in the recipient’s bone marrow.

What is FCR001?

Our lead product candidate, FCR001, is a one-time, investigational cell therapy that contains three distinct cell types: hematopoietic stem cells, facilitating cells, and aßTCR+ T-cells.

  • Hematopoietic stem cells (HSCs) are progenitor cells that are used to rebuild the hematopoietic and immune system of the recipient
  • Facilitating cells, a seminal discovery of our founder Dr. Suzanne Ildstad, which we believe to be responsible for fast and efficient engraftment of donor HSCs and reduced risk of GvHD
  • αßTCR+ T-cells are known to support HSC engraftment, but also increase the risk of acute GvHD; FCR001 incorporates an optimized number of these cells to promote engraftment while minimizing risk